For head and trunk, when lying down 2) With posture holding UE: arms outstretched, wrists mildly extended, fingers spread apart LE: legs flexed at hips and knees foot dorsi-flexed tongue: when protruded head and trunk: when sitting or standing 3) with Action(ACT) and Intention(INT): UE: finger to nose and other actions LE: toe to finger in flexed posture Definitions for 1-9 0 = None 1 = Slight. I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.Fahn, Tolosa, Marin Tremor Rating Scale 1-9 Tremor (rate tremor) 1) At rest (in repose). I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. The details of the IRB/oversight body that provided approval or exemption for the research described are given below:Įthics committee Commissie mensgebonden onderzoek (CMO) regio Arnhem-Nijmegen gave ethical approval for this work I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. This study was funded by the Dutch Brain Foundation (Hersenstichting) and the Benny Vleerlaag fonds. Trial NL6686 (Netherlands Trial Register) Funding Statement The authors have declared no competing interest. Our findings suggest pathophysiologic heterogeneity between patients with dystonic tremor syndrome, which mirrors clinical variability. Conclusions This study indicates that the cerebellum plays a causal role in the generation of (non-jerky) dystonic tremor syndrome.
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